Aim . High levels could also indicate a problem with the kidneys, as these organs get rid of waste products from the body to keep the blood clean. Generation of creatinine is determined by muscle mass and diet, whereas tubular secretion could be decreased by the use of medications such as trimethoprim and cimetidine (Tagamet). Low muscle mass can also result from malnutrition, or from eating a low-meat or low-protein diet. The blood urea nitrogen (BUN) and serum creatinine levels will be elevated in patients with CKD . Your lungs may also be checked for damage with a chest X-ray and lung biopsy. This means they can also be caused by other illnesses. Low levels may indicate that muscles are less strong or are deteriorating, for example with a disease such as muscular dystrophy (MD). There are four key causes of low creatinine: Levels of creatinine are often linked with muscle mass or the amount of muscle in the body, which can decrease with age or illness. The harm done to your kidneys, however, can result in kidney failure. There are immune-mediated damage and inflammation of the kidney filters. Loss of kidney function can cause a buildup of fluid or body waste or electrolyte problems. Common Autoimmune Diseases That Can Damage Organs: Part Two Causes and Treatments of Decreased Creatinine Levels However, your kidneys may have been slightly or heavily damaged. Using the current classification system, nearly 50 percent of U.S. adults older than 70 years have stage 3 CKD, and most have no evidence of albuminuria.5 Older patients with stage 3 CKD without proteinuria and stable creatinine levels on repeat testing at three to six months are unlikely to progress to end-stage renal disease and do not have increased mortality risk. Learn why a creatinine urine test is done, how to prepare for it, what to expect during the test, and how to interpret the results. There are three major reasons why your kidneys might be injured: lack of blood flow to the kidneys, blockage in urine flow that causes infections, or direct kidney damage by infections, medications, toxins, or autoimmune conditions. The doctor may suggest that you undergo a special blood filtering process (plasmapheresis) to remove harmful antibodies. GFR is approximately 120 to 130 mL per minute per 1.73 m2 in young adults, and decreases by an average of 1 mL per minute per 1.73 m2 per year after 30 years of age.9 A GFR less than 60 mL per minute per 1.73 m2 represents a loss of at least one-half of normal kidney function; below this level, there is an increased prevalence of CKD complications.
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