Merck Manual Professional Version. Water-soluble vitamins: Acute vitamin B2 deficiency results in: Deep red erythema Stomatitis Epidermal necrolysis (peeling skin) Chronic vitamin B2 deficiency causes: Angular cheilitis Prominent lingual papillae (papules on the tongue) Seborrhoeic dermatitis Doctors also look for signs, such as tenderness during movement and local swelling, that may indicate bleeding in deeper tissues. An abnormality in any of these factors can lead to excessive bleeding or bruising: Platelet disorders Overview of Platelet Disorders Platelets (sometimes called thrombocytes) are cell fragments produced in the bone marrow that circulate in the bloodstream and help blood to clot. Note where the lesions are situated. information highlighted below and resubmit the form. Case Two. A 35-year-old woman presents with bruising of the upper thighs. George JN, et al. Thrombocytopenia, which is a deficiency in blood platelets, can cause bleeding and bruising in the dermis similar to senile purpura. Those that cause purpuric rashes include meningococcal septicaemia, streptococcal septicaemia and diphtheria. The initial signs of senile purpura are purple or red bruises that have an irregular shape. Senile purpura | DermNet Doctors first ask questions about the person's symptoms and medical history. 216.444.5725 Appointments & Locations Request an Appointment Possible Causes Care and Treatment Verify no liver disease: Illustrated Case Studies. If your symptoms are more severe, treatment may include medications to boost your platelet count or surgery to remove your spleen. Note whether general easy bruising has been noticed. Later, if the disorder becomes severe, bleeding may occur. The management of the various diseases is found in the respective articles. Some doctors think it may be a feature of many disorders read more . A positive family history increases the risk of a bleeding disorder and is reason to initiate a work-up,10,11 especially in women with menorrhagia.12 Many bleeding disorders have an inheritance pattern, including the X-linked recessive hemophilias.
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