It also demonstrated over 90% effectiveness against the Gulf Coast tick and the American dog tick. For a complete listing of adverse reactions for Profender Topical Solution reported to the CVM see: http://www.fda.gov/ADEreports. Revolution spot-on products are applied to the surface of a small target area or spot of the skin, usually in front of the shoulders at the back of the neck. Select one or more newsletters to continue. can you use profender and revolution at the same time. Fleas. Before taking any measure that could be potentially harmful to your pet, it is always suggested to take the vets advice on the same. Isoxazolines have been associated with seizures in pets, though in my own experience, very uncommonly. The formulation and dosage schedule is designed to provide a minimum of 3 mg of emodepside and 12 mg of praziquantel . Revolution will start to kill and repel fleas from your cat or kitten within half an hour and then within 24 hours should be in full cycle. Profender: A Topical Spot-On Medication For Cats width: 115px; .medication-table h5{ As well as using Revolution, cleansing of the infested ears is recommended to remove the debris. By enhancing GABA release, selamectin essentially causes paralysis and death of the parasites it targets. Dr. Vanderhoof is also a copywriter specializing in the animal health field and founder of Paramount Animal Health Writing Solutions, which can be found at www.animalhealthcopywriter.com. AutoShip and Save 30 % . Safety Study in Heartworm Positive Cats: Cats artificially infected with adult heartworms harvested from dogs were treated topically with PROFENDER Topical Solution at 0X, 1X or 5X the recommended dose once a month for three treatments. According to the manufacturer, when newly applied, Revolution can start killing fleas within 12 hours with a majority killed within 24 hours. Revolution Plus contains the main ingredients selamectin and sarolaner. Compare Revolution and Revolution Plus for Cats - BudgetPetCare Reality: Insecticide Resistance in Fleas from DVM360 that refers to an article published in American Veterinarian that same year addresses this topic. FDA Approved? Products should be used before the expiration on the package. She has never had it before so I want to make sure to minimize the risk of any adverse reaction, but I am also leaving for two weeks soon so I'd rather be here to monitor here. To ensure the entire contents of the tube are administered, place the tip of the tube on the skin and squeeze the entire contents directly onto the skin. I hope thats helpful to you.