lar dermal compounded topical anesthetic.7 Profound is a topical anesthetic gel compounded from three anesthetic agents (10% lidocaine, 10% prilocaine, and 4% tetracaine). 0000013364 00000 n 0000004461 00000 n Participants were randomly assigned to either the 20% benzocaine control group or the 10% lidocaine, 10% prilocaine, and 4% tetracaine experimental group using a random number table generated using the runiform command in Stata (StataCorp, College Station, TX). Required fields are marked *. Smith GA, Strausbaugh SD, Harbeck-Weber C, Shields BJ, Powers JD, Hackenberg D. Smith GA, Strausbaugh SD, Harbeck-Weber C, Shields BJ, Powers JD. Both types of topical anesthetic showed similar impacts on alterations to heart rate. Compounded anesthetics are used by dentists and orthodontists before dental procedures to numb areas of the mouth. AJN The American Journal of Nursing107(10):29, October 2007. Compound topical anesthetics are neither FDA-regulated nor -unregulated. 0000011063 00000 n During the week before the study, the average pain score for participants was 4 or greater on the 010 pain scale. 0000092473 00000 n While patients may report allergies to local anesthetics, in the majority of cases the reactions are not immune-mediated. Comparing the Efficacy of a Compound Topical Anesthetic Versus Benzocaine: A Pilot Study To compare the effectiveness of a combination of 10% lidocaine, 10% prilocaine, and 4% tetracaine versus 20% benzocaine for use as a topical anesthetic agent prior to dental injections. Compounded mixtures such as lidocaine, epinephrine, tetracaine (LET) solutions, have replaced cocaine with lidocaine 4% because of their superior safety when applied to nonintact skin . Custom dermatological compounds that are efficacious and economical. 0000007353 00000 n The direct experience of pain during the injection procedure is a primary contributor to this fear.13, Topical anesthetics can reduce the pain felt during needle penetration in the administration of local anesthesia.4,5 Specifically, topical anesthetic helps to relieve anxiety and pain through both psychological and pharmacologic effects.3,57 Psychologically, subjects who are informed they are going to receive topical anesthetic may experience less anticipated pain and may experience decreased apprehension.68 Physiologically, reduction in pain is achieved by blocking nerve impulse conduction in the free nerve endings located within the superficial tissues through the temporary decrease of sodium ion permeability in the nerve cell membrane.4,9.
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