The relationship between odor perception and symptomatic reaction is complex, and the perception of a fragrance is partly determined by context and expectation. It was concluded that eye irritation, cough and shortness of breath could be provoked by perfume in these patients (Millqvist & Lwhagen 1996; Millqvist et al 1999). At Another Johns Hopkins Member Hospital. Multiple Chemical Sensitivity In 2004, polymorphisms in the cytochrome P450 2D6 (CYP2D6) allele responsible for variation in toxicant metabolism pathways differed in patients with MCS. Individual difference factors in animals that enhance the ability to become sensitized include parental preference for abusable substances (genetics),28 female gender (related in part to the progesterone-to-estrogen ratio),29 hyperreactivity to novel environments,30,31 and preference for sucrose rather than plain water.3235 Human self-report and laboratory studies have repeatedly shown parallel findings in persons with chemical intolerance, including familial substance abuse problems, greater prevalence of women affected, hyperreactivity of acoustic startle blink responses to novel noise stimuli during chemical exposure, and higher scores for carbohydrate and other food cravings on validated questionnaires.5. Kindling without a seizure has been shown to cause affective behavior changes in animals. One hypothesis states that individuals who have genetically or nutritionally defective enzyme detoxification systems might be more susceptible to exposure to low levels of chemicals. Studies show that patients with MCSmeet criteria for depression, anxiety, somatization, and obsessivecompulsive and personality disorders. My highest recommendation goes out to Jason. Some have suggested that cacosmia as well as MCS may be a manifestation of a stress response. WebMultiple chemical sensitivity See: Idiopathic environmental intolerance Stop the flu Be part of a health system that is truly world-class No other single employer in South Australia The pattern of symptoms is idiosyncratic to the patient, not to the exogenous agent. Compared with patients with MCS who can identify an initiating past chemical exposure, the subset of chemically intolerant patients who cannot identify a specific higher level chemical exposure event that initiated their condition presents with higher lifetime rates of psychiatric problems, especially anxiety and depression. Patients allegedly suffering from multiple chemical sensitivities complain of depression, excessive fatigue, sleep disorders, irritability, headaches, and symptoms, such as rhinitis, similar to those associated with allergies.
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